Biosolutions
Biosolutions Products
In the quest to naturally control pathogens and enhance overall animal health, Plaza Feed & Crop Nutrition offers broad-spectrum solutions, as well as kits that combine these solutions with highly targeted pathogen control using cutting-edge bacteriophage. We take pride in the synergistic performance of our Biosolutions. We offer 2 probiotic products and Bacteriophages (phages), combined with probiotics in a Phage Kit for superior performance. Our B11 probiotic has superior performance against Salmonella, working within the front part of the small intestine (jejunum) due to the 11-strain Lactobacillus cocktail. Conversely, Cecabiotics (Bacillus cocktail) is effective against pathogens that thrive in the pH of the back part of the intestines (cecal tubes). The Phage Kit uses phages that target specific pathogens, while our probiotics suppress other pathogens and further protect beneficial bacteria. Our two probiotics were developed in the esteemed Hargis lab of the Poultry Science Department at the University of Arkansas.
We deliver technically advanced products to support and enhance healthy animal functions, including:
- Microbiome enhancement
- Feed fortification precision nutrition
- Enzyme production
- Ulcer prevention & mitigation
- Bone & joint strength
- Gastric balance
- Enhanced feed conversion
- Weight gain
- Output yield
- Feed production binding
Your Source for Advantaged Biosolutions Products
Plaza Feed & Crop Nutrition (PFCN) currently the following products. Contact us today for more information. PFCN partners with biotech manufacturers to produce the following products in the USA.
Cecabiotics
Advanced Biosolution for Animal Health and Performance
Cecabiotics is an Advanced Biosolution representing a breakthrough in poultry health management, developed and patented by the University of Arkansas. Cecabiotics is not just a probiotic – it is a Day 1 gut health intervention designed to reduce early mortality, stabilize intestinal health, and deliver measurable performance gains throughout the entire production cycle. By acting at the most critical stage of a bird’s life, Cecabiotics creates a foundation that compounds into improved livability, efficiency, and profitability. It combines scientific innovation that enables practical application in water lines, delivering same-day improvements in animal welfare and production efficiency. Cecabiotics is a cocktail blend of 3 Bacillus strains that attack pathogens that thrive in the Cecal tubes. Cecabiotics is manufactured in Arkansas by one of our biotech partners.
Cecabiotics serves multiple functions:
- Reduced 7-day Mortality: Protecting Birds When It Matters Most
The first 7 days represent the most vulnerable period in a bird’s life. Cecabiotics targets early-stage pathogens, such as E. coli, to help chicks overcome placement stress and protect the intestinal lining, improving nutrient uptake. Reducing early microbial damage and preserving gut integrity allows Cecabiotics to lower early mortality rates, prevent irreversible intestinal damage, and set a stage for stronger, more uniform flocks. With every bird saved in the first week becoming a compounding asset for the entire grow-out period, Cecabiotics gives you more bang for your buck.
- From Day 1 to Harvest: Continuous Gut Health Support
Cecabiotics delivers benefits that extend far beyond early life. By stabilizing the microbiome in the cecal region, it supports sustained nutrient absorption, improved enzymatic digestion, strong skeletal development, and enhanced eggshell quality in layers and breeders. Leading to better feed conversion, higher body weight gain, and improved flock uniformity. Transforming early protection into full-cycle performance.
- Compounding Value: Early Gains, Large Final Returns
While Cecabiotics delivers immediate benefits, its true value lies in how those benefits accumulate over time. Through Day 1 intervention and limiting the pathogen cascade, early gut integrity is preserved, nutrient absorption improves, immune stress is greatly reduced, and performance gains build continuously. The result is not just a short-term improvement, but a compounding effect across the entire flock lifecycle, where lower early mortality leads to more birds in production, healthier intestines provide better feed efficiency, and that better efficiency creates healthier birds with improved final weights and returns. Cecabiotics doesn’t just solve problems, it prevents losses and multiplies gains over time.
- Pathogen Control: Stopping The Cascade Before It Starts
Early pathogen exposure often triggers a pathogen cascade, resulting in mortality, intestinal damage, poor absorption, and even secondary infections. Cecabiotics interrupts this process by targeting a wide spectrum of harmful organisms (E. coli, Clostridium perfringens (necrotic enteritis), Enterococcus cecorum, and Salmonella), stabilizing beneficial microflora, and preventing reinfection cycles. Controlling the first disruption prevents a chain reaction of performance losses caused by bad bacteria.
Fast Acting, Flexible and Safe
Our water line delivery lets you dose Cecabiotics quickly, easily, and effectively. Cecabiotics is a non-toxic, natural probiotic blend that improves flock health via key performance in the Cecal tubes. Unlike traditional feed-based interventions, which may take up to 14 days to reach a point of action, Cecabiotics delivers same-day impact via water-line application. Our patented organisms are harmonized for performance and processed to maintain enzymatic integrity and to rehydrate effectively, combating pathogens from day one. Cecabiotics actively defends against common poultry pathogens. When used from Day 1 placement, Cecabiotics reduces high 7-day mortality by reducing the pathogen cascade. By enhancing mineral absorption and energy conversion, Cecabiotics strengthens bones, improves eggshell quality, improves FCR, and increases BWG without the risk of overdose. An innovative solution such as Cecabiotics has long been sought by the protein live production community.
Phage Kits
Advanced Removal of Pathogens for Animal Health and Performance
Plaza has successively combined Cecabiotics, our high-performance, wide-spectrum probiotic, with the first commercially available Bacteriophage for Live production from our partner Intralytix into a Phage Kit. We utilize their Salmonella and E. coli phage cocktails, but will eventually start utilizing their Enterococcus cocktails. Intralytix produces the bacteriophages in Maryland, so both components of the kit are manufactured in the USA.
The Kit ensures that Cecabiotics and Phage are used together, with the Phage rapidly attacking target pathogens and Cecabiotics continuing to suppress other pathogens from emerging. The synergy between the two provides a comprehensive approach: Phage quickly reduces specific harmful bacteria, while Cecabiotics fills the resulting void and prevents further pathogen growth through competitive exclusion. This synergistic mechanism limits the pathogen cascade, reduces intestinal damage, and ensures long-term control over harmful bacteria while protecting beneficial microbiota. We must emphasize that the good bacteria are not removed by our Phage Kit, thus the intestinal microflora is more stable than other products.
The combined Kit products are delivered as a dry-powder kit for water-line administration or as a liquid phage for spray applications in the hatchery and the environment. The Phage Kit is normally deployed in the first week after placement. While proven effective in prevention, it is also effective in the recovery of infected flocks that were not administered our products from day 1. Additionally, the phage kit is highly effective for end-of-flock Salmonella treatment to meet pre-harvest specifications.
What is Bacteriophage?
Bacteriophages (phages) are highly specific antimicrobials, grouped into combinations targeting the most pathogenic serotypes of E. coli, Salmonella, Enterococcus, Listeria, and others. Phages serve as the natural predators of bacteria. They attach to bacterial cells, inject their genetic material, and utilize the cell’s machinery for replication, ultimately causing the cell to burst and release new phages. Bacteriophages naturally target harmful bacteria and leave beneficial bacteria untouched, protecting the microbiome without posing any risk to humans. Lytic bacteriophages kill target bacteria efficiently without harming the microbiome, offering safety and targeted pathogen control.
Growing antimicrobial resistance has created an urgent demand for natural solutions. Our phage kits enhance the effectiveness and longevity of antibiotics, addressing AMR concerns head-on.
Our partnership with Intralytix – Global Leader in Bacteriophage
Plaza Feed & Crop Nutrition holds the global exclusive for the Protein Live Production segment for phages from Intralytix, Inc.
Intralytix, Inc., in Columbia, Maryland, is a leader in bacteriophage-based products for food safety, health, veterinary, and environmental applications. Their pipeline includes FDA-cleared and USDA-approved products targeting antibiotic-resistant and foodborne pathogens.
Intralytix was the first globally to establish a Master Drug File with the FDA’s Center for Biologics Evaluation and Research for phage manufacturing suitable for human clinical applications. Additionally, it received the first FDA and USDA approvals for a phage product designed for food-safety applications. The company now boasts the world’s largest portfolio of FDA-and USDA-approved phage products targeting major foodborne bacterial pathogens. They are also the oldest phage company in the United States, pioneering nearly every aspect of phage-related development – from regulatory approvals to large-scale phage manufacturing under 21 CFR 117 cGMP conditions. It is also the only company in the world with Safe Quality Food (SQF) certification for phage manufacturing.
The company utilizes state-of-the-art facilities and technologies for developing and commercializing its phage products for food safety, nutraceutical, and other applications. These include 15 phage–phage technology patents, as well as proprietary PhaseSelector™ and AI-driven PhageEngine™ programs for designing the most effective phage formulations for targeted applications, and for scale-independent scale-up of phage manufacturing to fermenters exceeding 1,000 liters – the largest production capacity for FDA-approved phages in the United States.
Plaza Feed and Crop Nutrition is currently using Intralytix’s phage cocktails against E. coli and Salmonella.
BioSolutions B11
Advanced Biosolution for Animal Health and Performance
Plaza’s Biosolutions team has recently acquired the license for the highly regarded 11-strain Lactobacillus probiotic product that was also developed at the University of Arkansas. Historically, BioSolutions-B11 has globally exhibited premier performance against Salmonella and other pathogens that thrive in the front part of the small intestine (jejunum). Do not confuse B11 with the two-strain version of this highly regarded product. B11 is comprised of the exact 11 strains that impacted the Global market in preening spray applications, end-of-flock treatments, Salmonella control, etc.
Aleris Nutrition
Sugar cane derived yeast products for advanced animal nutrition
With a higher concentration of nutrients, Aleris’ line of natural products are known for delivering efficient results. Our US distribution focuses on products specific to the aquaculture, equine, and pet food sectors.
Cultron
Yeast culture with a wide diversity of metabolites produced during a controlled fermentation process and inactive cells of Saccharomyces cerevisiae that work in an integrated way contributing to the optimal utilization and performance of the animal
Maximos
A natural product made 100% from yeast cell wall (saccharomyces cerevisiae) to support intestinal integrity, digestive and immune systems with natural products for animal nutrition
GoldSac
Ingredient that combines fractions of fermented corn and high concentration of yeast, bringing high performance protein and energy source
Sinergis
Lysed yeast with high bioavailability of cytoplasm and cell wall elements. High quality and palatability nutritional source
Provillus
Balanced combination of extracts and yeast fractions with specific actions for dogs and cats
Nucleobase 1.5
Yeast-derived nutrient source with high content of free nucleotides